Shaquille O'Neal led the NBA in Points in 1999-00 with 61.
That is 10 more points than second-place Vince Carter.
| Rk | Player | Team | Date | Value |
|---|---|---|---|---|
| 1 | Shaquille O'Neal | LAL | 2000-03-06 | 61 |
| 2 | Vince Carter | TOR | 2000-02-27 | 51 |
| 3 | Karl Malone | UTA | 2000-04-22 | 50 |
| 4 | Clifford Robinson | PHX | 2000-01-16 | 50 |
| 5 | Allen Iverson | PHI | 2000-02-06 | 50 |
| 6 | Shaquille O'Neal | LAL | 2000-04-05 | 49 |
| 7 | Vince Carter | TOR | 2000-01-14 | 47 |
| 8 | Allen Iverson | PHI | 1999-11-10 | 46 |
| 9 | Tim Duncan | SAS | 2000-01-10 | 46 |
| 10 | Shaquille O'Neal | LAL | 2000-04-23 | 46 |
| 11 | Allen Iverson | PHI | 2000-01-03 | 45 |
| 12 | Nick Van Exel | DEN | 2000-04-15 | 44 |
| 13 | Larry Hughes | GSW | 2000-04-09 | 44 |
| 14 | Allen Iverson | PHI | 2000-03-22 | 44 |
| 15 | Elton Brand | CHI | 2000-04-13 | 44 |